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Androsterone Sodium Sulfate (RONE-S) Spray
Androsterone Sodium Sulfate (RONE-S) Spray
Brand: PheromoneXS
Product Code: RONES-SPRAY
Availability: 16

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AndrosteRONE Sodium Sulfate Pheromone Molecule



5α-ANDROSTAN-3α-OL-17-ONE SULPHATE, SODIUM SALT (Androsterone Sulfate) is a pheromone clinically recognized as one of the major androgen metabolites found in urine. Chemically related to Androsterone and DHEA(s) in structure. Scientific insights reveal this steroid hormone is sexual by design moreover works to reduce body aging. It is postulated that Androsterone Sulfate therefore projects a sexual, youthful signature while displaying warmer alpha status.

Some pheromone enthusiasts have compared Androsterone Sulfate to Androtics TAA (Molecule A) and have reported such. Our pheromone community researchers have stated that while Androsterone Sulfate is bright and cheerful it is however not as much as TAA. While the jury is still out whether this molecule is TAA pheromoneXS pledges to carry this for your testing purposes. Besides we really love it too.

Warming, light status enhancer, cheerful and while some equate it  with masculine undertones we feel its more of a mature status rather than masculine. It is because of this difference we suggest it as a pheromoneXS Unisexy molecule.

It is recommended females use less than men, but with proper blending techniques our lady testers have applied as much as 10 mcg per spray. As a standalone pheromone molecule the same ladies propose no more than 2.5 mcg per spray. Our male enthusiasts and researchers have applied as much as 50 mcg and sometimes above with excellent results.

As is typical with Sulfate Sodium Salt pheromone molecules storage in a cool dry location such as a freezer is ideal. We successfully have blended this molecule in several pheromoneXS blends and extensively tested its continued usability after prolonged exposure to sunlight. Our founder left a bottle of Bliss XS in his Jeep console over the Memphis summer (humid and very hot) and still proclaimed the same excellent results.


pheromoneXS Androsterone-Sulfate is available in 10 ml or 30 ml bottles as multiple different concentrations which you can select from 12.5 mcg per spray up to 500 mcg per spray. Bottles come with Perfumers Alcohol (SD40B) as diluent time set with 10% Dipropylene Glycol (DPG). Whichever strength you select, you are sure to get the full potential of the pheromone molecule. Perfectly blended pheromone mixes are now in your control enabling you to effortlessly create your own pheromone masterpiece.

10 and 30 ml Spray Bottle with atomizer, custom designed to your concentration specifications, will produce approximately: 10ml = 80 sprays / 30ml = 240 sprays. Each bottle consists of Androsterone-Sulfate pheromone molecule in solution of 90% Perfumers Alcohol (SD40B) with 10% Dipropylene Glycol (DPG) and are ready for immediate use.

Each spray will contain the requested dosage with a possible differential of up to +/- 6%

Important Information
You agree that by ordering any Pheromone Molecules you are ordering a custom product made specifically for you. This process requires lab time and can add 3-5 business days (Monday through Friday excluding holidays) to your order processing times. pheromoneXS strives to exceed customer expectations, but you should expect possible delays when ordering these. Please consider this when ordering retail and custom products together.


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Acta Med Hung. 1985;42(1-2):21-8.

Steroids excreted by human skin. II. C19-steroid sulphates in human axillary sweat.

Tóth I, Faredin I.

PMID: 3162156


Beside dehydroepiandrosterone sulphate and androsterone sulphate, 5-androstene-3 beta, 17 beta-diol-3-sulphate and testosterone sulphate were isolated and identified from the axillary sweat of sexually mature women and men. The quantities of these four C19-steroid sulphates were determined individually in the sweat of eight healthy, sexually mature women and men: dehydroepiandrosterone sulphate was found in the highest amount, it was followed by 5-androstene-3 beta, 17 beta-diol-3-sulphate and androsterone sulphate. Testosterone sulphate occurred in the lowest quantity, its excretion amounting to about one-thousandth of that of dehydroepiandrosterone sulphate. Study of the C19-steroid sulphates excreted by the apocrine sweat glands permitted an insight into the steroid metabolism in human skin, which presumably is, closely connected with the steroid hormones of peripheral blood.


J Clin Endocrinol Metab. 1993 Jan;76(1):112-6.

Androsterone sulfate: physiology and clinical significance in hirsute women.

Zwicker H1, Rittmaster RS.

PMID: 8380602


Androsterone sulfate (Andros-S) is the most abundant 5 alpha-reduced androgen metabolite in serum. To determine whether this steroid could serve as a marker of 5 alpha-reductase activity, we developed a specific RIA, using tritiated Andros-S to assess procedural losses. Baseline serum Andros-S levels (mumol/L; mean +/- SEM) in 14 hirsute women (3.0 +/- 0.4) were not reduced by ovarian suppression with leuprolide (3.0 +/- 0.3), but were decreased by 79% with combined ovarian and adrenal suppression with leuprolide and dexamethasone. The mean Andros-S level in polycystic ovarian syndrome (3.2 +/- 0.4) and in idiopathic hirsutism (3.5 +/- 0.5) was not significantly different from levels in normal women (3.0 +/- 0.5), but were significantly greater than levels in obese women (1.7 +/- 0.3; P < 0.05). The serum concentrations of Andros-S were about 10-fold greater than those of androsterone glucuronide and 100-fold greater than those of androstanediol glucuronide. Serum Andros-S concentrations correlated strongly with dehydroepiandrosterone sulfate (R = 0.59; P < 0.001) and to a lesser degree with androstanediol glucuronide and androsterone glucuronide (R = 0.28 and 0.49, respectively). There was a weak correlation with androstenedione levels and the androstenedione response to ACTH (R = 0.38 and 0.34, respectively), and no significant correlation with serum testosterone (R = 0.19). The ratio of any of the 5 alpha-reduced products (Andros-S, androstanediol glucuronide, and androsterone glucuronide) to precursors (androstenedione and testosterone) was not increased in hirsute women, suggesting that these women did not have a generalized increase in 5 alpha-reductase activity. In conclusion, these results confirm that Andros-S is the most abundant 5 alpha-reduced androgen metabolite in serum. It is primarily, if not exclusively, of adrenal origin in hirsute women. The fact that its levels were not elevated in hirsutism, although those of other adrenal androgens and androgen metabolites (androstanediol glucuronide and androsterone glucuronide) were, suggests that variations in sulfotransferase activity or metabolic clearance of Andros-S may be important determinants of serum Andros-S levels. Although Andros-S may be a marker of systemic 5 alpha-reductase activity, there was no evidence of a generalized increase in 5 alpha-reductase activity in hirsute women. Andros-S is therefore not recommended as a marker of either adrenal androgen production or of hirsutism.


Psychoneuroendocrinology. 2013 Aug;38(8):1299-309. doi: 10.1016/j.psyneuen.2012.11.014. Epub 2012 Dec 10.

Metabolomic profiles in individuals with negative affectivity and social inhibition: a population-based study of Type D personality.

Altmaier E1, Emeny RT, Krumsiek J, Lacruz ME, Lukaschek K, Häfner S, Kastenmüller G, Römisch-Margl W, Prehn C, Mohney RP, Evans AM, Milburn MV, Illig T, Adamski J, Theis F, Suhre K, Ladwig KH.

PMID: 23237813



Individuals with negative affectivity who are inhibited in social situations are characterized as distressed, or Type D, and have an increased risk of cardiovascular disease (CVD). The underlying biomechanisms that link this psychological affect to a pathological state are not well understood. This study applied a metabolomic approach to explore biochemical pathways that may contribute to the Type D personality.


Type D personality was determined by the Type D Scale-14. Small molecule biochemicals were measured using two complementary mass-spectrometry based metabolomics platforms. Metabolic profiles of Type D and non-Type D participants within a population-based study in Southern Germany were compared in cross-sectional regression analyses. The PHQ-9 and GAD-7 instruments were also used to assess symptoms of depression and anxiety, respectively, within this metabolomic study.


668 metabolites were identified in the serum of 1502 participants (age 32-77); 386 of these individuals were classified as Type D. While demographic and biomedical characteristics were equally distributed between the groups, a higher level of depression and anxiety was observed in Type D individuals. Significantly lower levels of the tryptophan metabolite kynurenine were associated with Type D (p-value corrected for multiple testing=0.042), while no significant associations could be found for depression and anxiety. A Gaussian graphical model analysis enabled the identification of four potentially interesting metabolite networks that are enriched in metabolites (androsterone sulfate, tyrosine, indoxyl sulfate or caffeine) that associate nominally with Type D personality.


This study identified novel biochemical pathways associated with Type D personality and demonstrates that the application of metabolomic approaches in population studies can reveal mechanisms that may contribute to psychological health and disease.

Copyright © 2012 Elsevier Ltd. All rights reserved.


Physiol Behav. 2000 Dec;71(5):435-40.

Androsterone sulfate increases dentate gyrus population spike amplitude following tetanic stimulation.

Urbanoski K1, Harris J, Gijsbers K, Dubrovsky B.

PMID: 11239660


We studied the effects of the androgenic hormone, androsterone sulfate, a 17-ketosteroid, on long term potentiation in the dentate gyrus (DG) of urethane anesthesized rats. Intravenous injection of 10 mg of the hormone dissolved in Nutralipid produced a significant increase of the population spike (PS), but not of the excitatory post-synaptic potentials (EPSP). The results are discussed in terms of the potential enhancement that androsterone sulfate may have on memory as was described for one of its parent compounds, dehydroepiandrosterone (DHEA) and its potential use as an antidepressant.

Pheromone Molecules
Documents ≥99% Certificate of Analasis
Synonyms ANDROSTERONE SULFATE SODIUM, Androsterone sulfate sodium salt, Sodium 5a-Androstan-3a-ol-17-one-d2 Sulfate, 3α-Hydroxy-5α-androstan-17-one 3-sulfate, 5α-Androstan-3α-ol-17-one sulfate, Rone-S, Rone-Sulfate, Sulphate, Andros-S

Canada - Regulated under CDSA (may not be available for import as a single molecule)

Australia - Unavailable for import under Prohibited Imports and Exports (Drugs and Precursor Chemicals)


Pheromone molecules removed from blends, because of government restrictions, have been carefully replaced with other acceptable components. At pheromoneXS we are dedicated to upholding the law, while also ensuring your complete satisfaction. We stand behind the integrity of every blend we make and promise the results are just as good or better with the replacement molecules we use. Its just like wearing the same XS blend you know and love. We guarantee it!


CAS Number 1852-41-1
Empirical Formula (Hill Notation) C19 H29 Na O5 S
Molecular Weight 392.49
Melting Point 145-148˚C
Application 5α-ANDROSTAN-3α-OL-17-ONE SULPHATE, SODIUM SALT (Androsterone Sulfate Sodium Salt) is a pheromone clinically recognized as one of the major androgen metabolites found in urine. Decidedly bright and cheerful with an alpha aura that softens tense situations, curbs anxiety and adds status. Perfect as a tempering molecule for heavier, more abrupt pheromones such as Androsterone, Androstanone and Andrtostenone this pheromone molecule is useful by both men and women.

Androsterone Sodium Sulfate (RONE-S) Spray - Reviews

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