Alpha-AndrosteNOL Pheromone Molecule
16, (5α)-ANDROSTEN-3α-OL (Alpha-Androstenol) is a pheromone that is produced in both men and women and is considered a social while displaying sexual aspects. This molecules fragrance has been described as musky with hints of sandalwood, or sweet vanilla (Sandalwood: woody, earthy, spicy and sometimes acrid).
Although considered mostly for social usage Alpha-Androstenol has contributed, in study, to both men and women appearing as sexier, more attractive and approachable as opposed to those without. It has been revealed in additional studies that Alpha-Androstenol creates a warming comfort in those exposed to its signature.
In females the presence of this attractiveness coupled with the emotional state of comfort produces an acute rise in lutropin in the anterior pituitary gland which is known to trigger ovulation. It is therefore concluded that Alpha-Androstenol when used properly can be steered to switch on sexual attraction spikes.
Alpha-Androstenol however, is mostly used as a buffering pheromone to take the edge off more aggressive pheromones like Androstenone. The primary function of its signature can be described as social, chattiness, receptive, comforting, warmth, approachability, happy-go-lucky, attractiveness, openness, and friendly. Contrary to its primary chemical signature when worn in the presence of male to male, it reduces status and is associated with beta-like or weakness.
Our pheromoneXS crowd-sourced research community recognizes Alpha-Androstenol as a staple of any good pheromone collection. Accordingly this versatile molecule can be used to steer interactions to a lighter, party like environment while creating sexual attraction. On the reverse spectrum it can be used as a tempering agent for anyone perceived as arrogant, bitchy or standoffish. Alpha-Androstenol is one of only a few pheromone molecules that sometimes have women approaching and opening men.
pheromoneXS loves Alpha-Androstenol and we are certain you will too. Best practice is to start with 12.5 mcgs per drop and work your way up. Find the best application for you. Go about your life, smile and be happy.
pheromoneXS Alpha-Androstenol is available in 10ml bottle as multiple different concentrations which you can select from 5 mcg per drop up to 100 mcg per drop. Bottles come with Dipropylene Glycol (DPG) as diluent. Whichever strength you select, you are sure to get the full potential of the pheromone molecule. Perfectly blended pheromone mixes are now in your control enabling you to effortlessly create your own pheromone masterpiece.
10ml Amber Bottle with attached dropper custom designed to your concentration specifications, will produce approximately: 10ml = 300 drops. Each bottle consists of Alpha-Androstenol pheromone molecule in solution of Dipropylene Glycol (DPG) and are ready for immediate use.
Each drop will contain the requested dosage with a possible differential of up to +/- 6%
You agree that by ordering any Pheromone Molecules you are ordering a custom product made specifically for you. This process requires lab time and can add 3-5 business days (Monday through Friday excluding holidays) to your order processing times. pheromoneXS strives to exceed customer expectations, but you should expect possible delays when ordering these. Please consider this when ordering retail and custom products together.
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Nature. 1998 Oct 8;395(6702):612-5.
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta.
Forman BM1, Tzameli I, Choi HS, Chen J, Simha D, Seol W, Evans RM, Moore DD.
The orphan receptor CAR-beta binds DNA as a heterodimer with the retinoid-X receptor and activates gene transcription in a constitutive manner. Here we show that, in contrast to the classical nuclear receptors, the constitutive activity of CAR-beta results from a ligand-independent recruitment of transcriptional co-activators. While searching for potential ligands of CAR-beta, we found that the steroids androstanol and androstenol inhibit the constitutive activity of CAR-beta. This effect is stereospecific: only 3alpha-hydroxy, 5alpha-reduced androstanes are active. These androstanes do not interfere with heterodimerization or DNA binding of CAR-beta; instead, they promote co-activator release from the ligand-binding domain. These androstane ligands are examples of naturally occurring inverse agonists that reverse transcriptional activation by nuclear receptors. CAR-beta (constitutive androstane receptor-beta), therefore, defines an unanticipated steroidal signalling pathway that functions in a manner opposite to that of the conventional nuclear receptor pathways.
Biological Psychology 1986-04-01
Effects of androstenol on human sexual arousal.
D Benton, V Wastell
The hypothesis that 5-alpha-androst-16-en-3 alpha-ol increases the sexual arousal of the human female was examined. This substance is produced by the male and has been suggested to be a possible human pheromone. Groups of female subjects were asked to read either a neutral or a sexually-arousing passage in the presence of either androstenol or a placebo. Although sexual arousal was clearly manipulated by the experimental conditions, there was no evidence that androstenol influenced sexual feelings.
The Journal of Steroid Biochemistry and Molecular Biology 1991-10-01
Human exposure to putative pheromones and changes in aspects of social behaviour.
J J Cowley, B W Brooksbank
Student volunteers (38 of each sex) were exposed unknowingly overnight to the vapour of pheromonally active substances and compared with controls. The substances were either 5 alpha-16-androsten-3 alpha-ol (androstenol, occurring in human underarm sweat, and known to be pheromonally active in pig and man), or a mixture of short-chain fatty acids (occurring in human vaginal fluid, and known to be sexually attractive to the male rhesus monkey). The following morning, the subjects provided information about their social exchanges since rising, by recording on a standardized test diagram the number, depth, duration and direction of initiation, of all verbal exchanges with other individuals. Irrespective of treatment, males returned significantly higher scores than did females for all exchanges and also for some exchanges initiated by other males. Neither exposure to androstenol nor to the fatty acids had any significant effects on any of the scores of males interacting with either sex, nor on any scores of females with other females. However, exposure of females to androstenol, but not to the fatty acids, resulted in significantly higher scores of exchanges with males, in terms of all parameters for all exchanges. Findings are considered in relation to the origin and maintenance across species of pheromonal communication: evolutionary conservation is seen in terms of the utilization of substances that have provided the means of controlling the social milieu.
Journal of Pharmacology and Experimental Therapeutics 2006-05-01
The pheromone androstenol (5 alpha-androst-16-en-3 alpha-ol) is a neurosteroid positive modulator of GABAA receptors.
Rafal M Kaminski, Herbert Marini, Pavel I Ortinski, Stefano Vicini, Michael A Rogawski
Androstenol is a steroidal compound belonging to the group of odorous 16-androstenes, first isolated from boar testes and also found in humans. Androstenol has pheromone-like properties in both animals and humans, but the molecular targets of its pheromonal activity are unknown. Androstenol is structurally similar to endogenous A-ring reduced neurosteroids that act as positive modulators of GABA(A) receptors. Here we show that androstenol has neurosteroid-like activity as a GABA(A) receptor modulator. In whole-cell recordings from cerebellar granule cells, androstenol (but not its 3beta-epimer) caused a concentration-dependent enhancement of GABA-activated currents (EC(50), 0.4 microM in cultures; 1.4 microM in slices) and prolonged the duration of spontaneous and miniature inhibitory postsynaptic currents. Androstenol (0.1-1 microM) also potentiated the amplitude of GABA-activated currents in human embryonic kidney 293 cells transfected with recombinant alpha1beta2gamma2 and alpha2beta2gamma2 GABA(A) receptors and, at high concentrations (10-300 microM), directly activated currents in these cells. Systemic administration of androstenol (30-50 mg/kg) caused anxiolytic-like effects in mice in the open-field test and elevated zero-maze and antidepressant-like effects in the forced swim test (5-10 mg/kg). Androstenol, but not its 3beta-epimer, conferred seizure protection in the 6-Hz electroshock and pentylenetetrazol models (ED(50) values, 21.9 and 48.9 mg/kg, respectively). The various actions of androstenol in the whole-animal models are consistent with its activity as a GABA(A) receptor modulator. GABA(A) receptors could represent a target for androstenol as a pheromone, for which it is well suited because of high volatility and lipophilicity, or as a conventional hormonal neurosteroid.
Biol Psychol. 1982 Nov-Dec;15(3-4):249-56.
The influence of androstenol - a putative human pheromone - on mood throughout the menstrual cycle.
Each morning for a month female subjects placed either 5 alpha-androst-16-en-3 alpha-ol, a putative human pheromone, or a placebo on the upper lip. Each evening the subjects rated on five scales their moods during that day. In the middle of their monthly cycle those females exposed to androstenol rather than a control tended to rate their moods as submissive rather than aggressive. The compound did not significantly influence ratings of being happy/depressed; lethargic/lively; sexy/unsexy; irritable/good-tempered. The results are discussed in terms of the possible increased olfactory sensitivity of the human female to androstenol in the middle of her monthly cycle.
|Molecular Name||16, (5α)-ANDROSTEN-3α-OL|
IR TEST: Conforms
|Synonyms||Alpha-Androstenol, ANOL, alphanol, 16-(5α)Androsten-3α-ol, 3α-Hydroxy-5α-androst-16-ene|
|Empirical Formula (Hill Notation)||C19 H30 O|
|Application||5alpha-androst-16-en-3alpha-ol (androstenol), is an androgen that acts as a pheromone. In humans it is circulated via the adrenal gland and has been detected in sweat, saliva and urine. Used primarily for its social aspects such as chattiness, flirting, engagement and relative light fun.|