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Androstadienone (DIENONE A1) DPG
Androstadienone (DIENONE A1) DPG
Brand: PheromoneXS
Product Code: A1-DPG
Availability: 27

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AndrostaDIENONE A1 Pheromone Molecule




Androsta-4,16,-dien-3-one (Androstadienone A1) is a pheromone produced by male humans and can be found in sweat, saliva and semen. This pheromone molecule has been associated with the smell of urine, musk and body odor. We highly recommend using a cover fragrance with it.

One of the most extensively studied pheromone molecules, Androstadienones persuasive impact on women is impressive. You can be assured to expect feelings of comfort, relaxation, attraction, skin sensitivity and arousal. Directly linked to an increase of activity in the hypothalamus, this correlates to studies that reveal heightened sexual activity. Androstadienone, as a pheromone, is functionally olfactory but there are claims that suggests an unequivocal association with increased neural activity without exposure to odor. Either way Androstadienone elevates attraction spikes in women when worn by men.

The pheromoneXS research community has established through personal experimentation and usage the amazing benefits of Androstadienone while tempering, or eliminating adverse effects. One such adverse effect has been identified with depression and/or lethargy in men. Some pheromone vendors have discontinued selling it on this premise, while others disregard the consequences while failing to eliminate these reactions. Without the advantages of personal usage and a research community dedicated to such, it is unfortunate many consumers will still experience the associated downside typical of mass-marketed products.

While acting to soothe and calm women Androstadienone influences an emotional response of elevated attraction with tactile sensitivity. Accordingly, when perfectly tempered with specifically chosen pheromone molecules pheromoneXS has effectively invalidated any adverse effects. Our precise attention to detail can only come from our passion for pheromones you will not find anywhere else.

Androstadienone as an individual pheromone molecule should therefore be approached with a sense of caution. We recommend a starting dosage of 2.5 mcgs per spray (available in our 30 ml size option on spray bottles only) with incremental advances. Our personal experiences have yielded fantastic results with as much as 50 mcgs per drop, but only when tempered correctly. Other pheromone molecules to consider for usage are: Androstenone, Alpha and Beta Androstenol, Beta Androstanol, DHEA, Androsterone Sodium Sulfate and research molecules XSR37 and XSR68.

This is a highly recommended molecule that creates significant attraction spikes in women while enticing them to feel your touch on their sensitive skin, activating sexual arousal. What more can you ask of a pheromone molecule?


pheromoneXS Androstadieone is available in 10ml bottle as multiple different concentrations which you can select from 5 mcg per drop up to 100 mcg per drop. Bottles come with Dipropylene Glycol (DPG) as diluent. Whichever strength you select, you are sure to get the full potential of the pheromone molecule. Perfectly blended pheromone mixes are now in your control enabling you to effortlessly create your own pheromone masterpiece.

10ml Spray Bottle with attached dropper custom designed to your concentration specifications, will produce approximately: 10ml = 300 drops. Each bottle consists of Androstadieone pheromone molecule in solution of Dipropylene Glycol (DPG) and are ready for immediate use.

Each spray will contain the requested dosage with a possible differential of up to +/- 6%

Important Information
You agree that by ordering any Pheromone Molecules you are ordering a custom product made specifically for you. This process requires lab time and can add 3-5 business days (Monday through Friday excluding holidays) to your order processing times. pheromoneXS strives to exceed customer expectations, but you should expect possible delays when ordering these. Please consider this when ordering retail and custom products together.

Dropper Types

All Oil Bottles are shipped with a white Euro Dropper. You may request an optional Bulb Dropper to be included on the side.

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J Neurosci. 2007 Feb 7;27(6):1261-5.

Smelling a single component of male sweat alters levels of cortisol in women.

Wyart C1, Webster WW, Chen JH, Wilson SR, McClary A, Khan RM, Sobel N.

PMID: 17287500


Rodents use chemosignals to alter endocrine balance in conspecifics. Although responses to human sweat suggest a similar mechanism in humans, no particular component of human sweat capable of altering endocrine balance in conspecifics has yet been isolated and identified. Here, we measured salivary levels of the hormone cortisol in women after smelling pure androstadienone (4,16-androstadien-3-one), a molecule present in the sweat of men that has been suggested as a chemosignal in humans. We found that merely smelling androstadienone maintained significantly higher levels of the hormone cortisol in women. These results suggest that, like rodents, humans can influence the hormonal balance of conspecifics through chemosignals. Critically, this study identified a single component of sweat, androstadienone, as capable of exerting such influence. This result points to a potential role for synthetic human chemosignals in clinical applications.



Psychoneuroendocrinology. 2004 Nov;29(10):1290-9.

Sniffing a human sex-steroid derived compound affects mood and autonomic arousal in a dose-dependent manner.

Bensafi M1, Tsutsui T, Khan R, Levenson RW, Sobel N.

PMID: 15288708


The effects of sniffing different concentrations of the human sex-steroid derived compound 4,16-androstadien-3-one (AND) on autonomic nervous system function and mood were measured in 60 subjects. The effects were sex-specific and concentration-dependent. Only high concentrations of AND (0.00625 M) increased positive mood (p < 0.03) and decreased negative mood (p < 0.05) in women compared to men, and had sympathetic-like effects in women (p < 0.003), and parasympathetic-like effects in men (p < 0.05). These findings further implicate AND in chemical communication between humans, but pose questions as to the path by which AND is transduced, whether through chemical sensing or transdermal diffusion.



Behav Neurosci. 2003 Dec;117(6):1125-34.

Sex-steroid derived compounds induce sex-specific effects on autonomic nervous system function in humans.

Bensafi M1, Brown WM, Tsutsui T, Mainland JD, Johnson BN, Bremner EA, Young N, Mauss I, Ray B, Gross J, Richards J, Stappen I, Levenson RW, Sobel N.

PMID: 14674833


The physiological and psychological effects of 2 human sex-steroid derived compounds, 4.16-androstadien-3-one (AND) and l,3,5(10),16-estratetraen-3-ol(EST) were measured in 24 subjects who participated in a within-subjects, double-blind experiment. A dissociation was evident in the physiological effects of AND, in that it increased physiological arousal in women but decreased it in men. EST did not significantly affect physiological arousal in women or men. Neither compound significantly affected mood. AND is an androgen derivative that is the most prevalent androstene in human male sweat, male axillary hair, and on the male axillary skin surface. The authors argue that AND's opposite effects on physiology in men and women further implicate this compound in chemical communication between humans.


Horm Behav. 2008 Nov;54(5):597-601. doi: 10.1016/j.yhbeh.2008.06.001. Epub 2008 Jun 14.

Evidence that androstadienone, a putative human chemosignal, modulates women's attributions of men's attractiveness.

Saxton TK1, Lyndon A, Little AC, Roberts SC.

PMID: 18601928


Considerable research effort has focused on whether specific compounds found within human body odor influence the behavior or physiology of other individuals. The most intensively studied is 4,16-androstadien-3-one, a chemical which is known to modulate mood and have activational effects in the sympathetic nervous system in a context-dependent manner, but whose action in mate-choice contexts remains largely untested. Here we present evidence that this androgen steroid may modulate women's judgments of men's attractiveness in an ecologically valid context. We tested the effects of androstadienone at a speed-dating event in which men and women interacted in a series of brief dyadic encounters. Men were rated more attractive when assessed by women who had been exposed to androstadienone, an effect that was seen in two out of three studies. The results suggest that androstadienone can influence women's attraction to men, and also that research into the modulatory effects of androstadienone should be made within ecologically valid contexts.


Curr Med Chem. 2011;18(8):1213-9.

Is androstadienone a putative human pheromone?

Marazziti D1, Torri P, Baroni S, Catena Dell'Osso M, Consoli G, Boncinelli V.

PMID: 21291365


On the basis of different evidences, androstadienone, a steroid compound produced in the armpit, has been proposed as a human pheromone, although its physiological levels appear too low to induce a response under experimental conditions. For this reason, the majority of researchers in this area puts into question the "legitimacy" of androstadienone, and prefers to consider the axillary extracts in its entirety, like a sort of "medicinal tea", the components of which still remain to be identified, but that taken together may induce a response, or function as a carrier of other active substances. Another option is that androstadienone acts with varying degrees of potency and, at lower concentrations, according to the context and to specific behavioral situations. The aim of this paper is to review all relevant data regarding androstadienone, in order to ascertain whether it may be considered a physiological pheromone and, as such, a possible target of future modulators of some human behaviors.


Biol Psychol. 2005 Dec;70(3):197-204. Epub 2005 Mar 24.

Subthreshold amounts of social odorant affect mood, but not behavior, in heterosexual women when tested by a male, but not a female, experimenter.

Lundström JN1, Olsson MJ.

PMID: 16242537


Previously, we have demonstrated that exposure to the endogenous steroid androstadienone has the ability to modulate women's mood in that they feel more focused [Lundstrom, J.N., Goncalves, M., Esteves, F., Olsson, M.J., 2003a. Psychological effects of subthreshold exposure to the putative human pheromone 4,16-androstadien-3-one. Hormones and Behaviour 44 (5), 395-401]. Here, we tested the hypothesis that androstadienone exposure would modulate participating women's mood and corresponding behavior as measured by a sustained attention task. Thirty-seven women participated in a double-blind, within-group experiment and were tested by either a female or a male experimenter. Effects on mood, psychophysiological arousal, sustained attention, and ratings of male facial attractiveness were assessed. Sensory detection of the experimental substance was rigorously controlled for by psychophysical testing. The results showed that exposure to a non-detectable amount of androstadienone modulated women's psychophysiological arousal and mood in a positive direction but did not change attention performance or rating of facial attractiveness. Moreover, mood effects were only evident when an experimenter of the opposite sex conducted the testing. This suggests that social context is important for mood effects of androstadienone exposure in women.


Horm Behav. 2009 Apr;55(4):548-59. doi: 10.1016/j.yhbeh.2009.01.002. Epub 2009 Jan 20.

Putative human pheromone androstadienone attunes the mind specifically to emotional information.

Hummer TA1, McClintock MK.

PMID: 19470369


The putative human pheromone Delta4,16-androstadien-3-one (androstadienone), a non-androgenic steroid found in sweat and saliva, modulates psychological, physiological and hormonal responses without detection as an odor. To determine the specific psychological processes altered by androstadienone, four studies were completed by 50 men and women after solutions of 250 microM androstadienone or clove-odor control carrier, on separate days, were applied to their upper lip: (1) face pairs were subliminally presented, with one face neutral and the other happy or angry. Androstadienone accelerated speed to locate a subsequent dot probe appearing on the same side as emotional faces, without affecting overall reaction times, indicating that androstadienone specifically enhanced automatic attention to emotional information. (2) In two Stroop paradigms, emotional or mismatched color words interfered with ink color identification. Androstadienone slowed ink color identification of emotional words, demonstrating greater allocation of attentional resources towards emotional information, with no effect on the cognitive Stroop. (3) To test effects on social cognition, participants performed two working memory tasks with distinct stimuli, neutral faces or shapes. Androstadienone did not alter attention to either the social or nonsocial images. (4) The ameliorative effects of androstadienone on self-reported attentiveness were replicated, consistent with increased attention to emotional visual stimuli. Moreover, androstadienone did not alter positive or negative mood, as participants were alone during testing, which removed emotional stimuli from social interactions with a tester. Taken together, these findings demonstrate that subliminal androstadienone guides psychological resources to specifically engage stimuli with emotional significance and does not alter attention to social or general cognitive information.

Pheromone Molecules
Molecular Name androsta-4,16,-dien-3-one

≥99% Certificate of Analasys

IR TEST: Conforms

Synonyms Androstadienone, A1, (8S,9S,10R,13R,14S)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-one
CAS Number 794-58-9
Empirical Formula (Hill Notation) C19H26O
Molecular Weight 270.40914
Melting Point 138-138.5˚C
Application Androsta-4,16,-dien-3-one (AndrostaDIENONE) is a pheromone detected in male sweat, saliva and semen. Androstadienone is considered a comforting pheromone molecule and has been extensively studied. Best used to invoke a sense of closeness with females, but is reported to cause depression and lethargy in some males. Properly tempered you can expect compliance, touching, closeness and sexual attraction.

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