pregNENOlone Pheromone Molecule
5-PREGNEN-3β-OL-20-ONE (PregNENOlone) is a pheromone classified as a neurosteroid (a rare steroid that is produced in the brain rather than other sources such as peripheral). Produced in both men and female it is predominantly associated with well-being and mood elevation. While a common scent has not been associated with pregnenolone it has been closely associated with enhancing ones own sense of smell and sight.
Pregnenolone is perhaps the only reported pheromone molecule that can create an effect by utilizing as a spray or oil applied to skin, or subsequently ingested as a supplement. Some of our DiscoverXS community researchers have previously reported an elevation of mood and increased cognitive functions when ingested, while others claim significant increased social reactions.
The revered Tacitus from Androtics pherotalk had suggested it acted like a “brain switch went click and they warped into very social behavior.”. He further surmised that while wearing it as a pheromone it delivered a powerful biological signal that implied the wearer was so healthy and awash in pregnenolone those exposed would have to take notice.
As to the nature of claiming social over sexual reactions the research is ongoing. It is perhaps because pregnenolone readily converts into sexual hormones internally it has also been labeled as a sexual pheromone. However from personal experiences it is widely recognized to elevate mood of both the wearer and the exposed. While some others propose an escalation in flirting and even sexual behavior it can be postulated that the elevation of mood contributes directly to this rather than the molecule itself. The evidence for social patterning through mood elevation is dependable while sexual patterning is intermittent.
The best possible way to determine personal results is always evaluate the effects of the molecule on yourself and those you are exposing to it. While pheromoneXS can provide you with pregnenolone in spray and oil concentrations, this is not for human consumption. Our pheromone molecules are designed to apply to skin as cologne. Any information on the consumption of pregnenolone as a supplement is strictly for reference purposes only. We do not make any claim as to the results of any supplement and are only referencing either personal experiences or the experience of others.
If you’d like to participate in researching this pheromone molecule along with all the others we currently offer at a 30% discount or more, please join us on DiscoverXS.com. We are crowd-sourcing the advancement of pheromone research and would love for you to join us. Either way pregnenolone is one of those exciting and interesting pheromone molecules everyone should get on board with.
There are reports of great results at below 25 mcg per spray as well as great results above as much as 100 mcg per spray. We would recommend starting at 12.5 mcg per spray and working your way up to where you feel comfortable and are getting the best results. A great molecule to be paired with other socials, sexuals or as a stand-alone.
pheromoneXS Pregnenolone is available in 10 ml or 30 ml bottles as multiple different concentrations which you can select from 12.5 mcg per spray up to 500 mcg per spray. Bottles come with Perfumers Alcohol (SD40B) as diluent time set with 10% Dipropylene Glycol (DPG). Whichever strength you select, you are sure to get the full potential of the pheromone molecule. Perfectly blended pheromone mixes are now in your control enabling you to effortlessly create your own pheromone masterpiece.
10 and 30 ml Spray Bottle with atomizer, custom designed to your concentration specifications, will produce approximately: 10ml = 80 sprays / 30ml = 240 sprays. Each bottle consists of Pregnenolone pheromone molecule in solution of 90% Perfumers Alcohol (SD40B) with 10% Dipropylene Glycol (DPG) and are ready for immediate use.
Each spray will contain the requested dosage with a possible differential of up to +/- 6%
You agree that by ordering any Pheromone Molecules you are ordering a custom product made specifically for you. This process requires lab time and can add 3-5 business days (Monday through Friday excluding holidays) to your order processing times. pheromoneXS strives to exceed customer expectations, but you should expect possible delays when ordering these. Please consider this when ordering retail and custom products together.
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Pharmacol Rep. 2010 Nov-Dec;62(6):1030-40.
Effects of neurosteroids on the human corticotropin-releasing hormone gene.
Budziszewska B1, Zając A, Basta-Kaim A, Leśkiewicz M, Steczkowska M, Lasoń W, Kaciński M.
Increased activity of hypothalamic-pituitary-adrenal (HPA) axis and hypersecretion of corticotropin-releasing hormone (CRH) are known to be important factors in pathogenesis of some stress-related diseases. Some neurosteroids exert anxiolytic and antidepressant effects probably by inhibition of HPA axis activity. The aim of our study was to find out if neurosteroids can directly affect human CRH gene transcription. The effect of allopregnanolone (ALLO), allotetrahydrodeoxycorticosterone (THDOC), pregnenolone (PGL), PGL sulfate (PGL-S), dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) on CRH expression was determined in differentiated Neuro-2A cells stably transfected with plasmid containing a fragment of human CRH promoter (-663 to + 124 bp) linked to the chloramphenicol acetyltransferase (CAT) reporter gene. It was found that PGL (0.3-30 μM), ALLO (1-30 μM) and THDOC (1-30 μM) present in the culture medium for 5 days in the concentration-dependent manner inhibited CRH-CAT activity. These neurosteroids also inhibited forskolin-stimulated CRH gene transcription with similar potency. In contrast, PGL-S, DHEA and DHEA-S in a concentration from 0.01 to 10 μM had no effect on basal and forskolin-stimulated CRH activity. Further experiments revealed that wortmannin (an inhibitor of phosphatidylinositol 3-kinase; PI3-K) at concentrations of 0.01 and 0.02 μM did not change the inhibitory effect of ALLO (3 μM) and PGL (1 μM) on CRH gene transcription. Moreover, ALLO (3 μM) and PGL (1 μM) present in the culture medium for 5 days did not change the amount of active, phosphorylated form of protein kinase B (PKB, Akt) and extracellular signal-regulated kinase (ERK). The obtained results indicate that PGL, ALLO and THDOC inhibited basal and forskolin-induced CRH gene promoter activity in the differentiated Neuro-2A cells and that these effects did not depend on the activation of PI3-K/Akt and ERK-MAPK pathways.
Hum Brain Mapp. 2014 Jul;35(7):3249-61. doi: 10.1002/hbm.22399. Epub 2013 Dec 2.
The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity.
Sripada RK1, Welsh RC, Marx CE, Liberzon I.
The neurosteroids allopregnanolone and dehydroepiandrosterone (DHEA) are integral components of the stress response and exert positive modulatory effects on emotion in both human and animal studies. Although these antidepressant and anxiolytic effects have been well established, to date, little research has examined their neural correlates, and no research has been conducted into the effects of neurosteroids on large-scale networks at rest. To investigate the neurosteroid impact on intrinsic connectivity networks, participants were administered 400 mg of pregnenolone (N = 16), 400 mg of DHEA (N = 14), or placebo (N = 15) and underwent 3T fMRI. Resting-state brain connectivity was measured using amygdala as a seed region. When compared with placebo, pregnenolone administration reduced connectivity between amygdala and dorsal medial prefrontal cortex, between amygdala and precuneus, and between amygdala and hippocampus. DHEA reduced connectivity between amygdala and periamygdala and between amygdala and insula. Reductions in amygdala to precuneus connectivity were associated with less self-reported negative affect. These results demonstrate that neurosteroids modulate amygdala functional connectivity during resting state and may be a target for pharmacological intervention. Additionally, allopregnanolone and DHEA may shift the balance between salience network and default network, a finding that could provide insight into the neurocircuitry of anxiety psychopathology. Hum Brain Mapp 35:3249-3261, 2014. © 2013 Wiley Periodicals, Inc.
Copyright © 2013 Wiley Periodicals, Inc.
Behav Processes. 2013 Oct;99:130-7. doi: 10.1016/j.beproc.2013.07.001. Epub 2013 Jul 13.
The role of pregnenolone sulphate in spatial orientation-acquisition and retention: an interplay between cognitive potentiation and mood regulation.
Plescia F1, Marino RA, Cannizzaro E, Brancato A, Cannizzaro C.
Neurosteroids can alter neuronal excitability interacting with specific neurotransmitter receptors, thus affecting several functions such as cognition and emotionality. In this study, we investigated, in adult male rats, the effects of the acute administration of pregnenolone-sulfate (PREGS) (10 mg/Kg, s.c.) on cognitive processes using the Can test, a non aversive spatial/visual task which allows the assessment of spatial information-acquisition during the baseline training, and of memory retention in the longitudinal study. Furthermore, on the basis of PREGS pharmacological profile, the modulation of depressive-like behaviour was also evaluated in the forced swim test (FST). Our results indicate that acute PREGS induces: an improvement in spatial orientation-acquisition and in reference memory, during the baseline training; a strengthening effect on reference and working memory during the longitudinal study. A decrease in immobility time in the FST has also been recorded. In conclusion, PREGS exerts enhancing properties on acquisition, consolidation and retrieval of spatial information, probably due of improved hippocampal-dependent memory processes. The additional antidepressant effect observed in the FST can provide further evidence in support of the potential of PREGS as a therapeutic tool for the treatment of cognitive deficits associated with mood disorders. This article is part of a Special Issue entitled: insert SI title.
Copyright © 2013 Elsevier B.V. All rights reserved.
Biol Psychiatry. 2013 Jun 1;73(11):1045-53. doi: 10.1016/j.biopsych.2012.12.008. Epub 2013 Jan 21.
Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits.
Sripada RK1, Marx CE, King AP, Rampton JC, Ho SS, Liberzon I.
The neurosteroid allopregnanolone is a potent allosteric modulator of the gamma-aminobutyric acid type A receptor with anxiolytic properties. Exogenous administration of allopregnanolone reduces anxiety, and allopregnanolone blockade impairs social and affective functioning. However, the neural mechanism whereby allopregnanolone improves mood and reduces anxiety is unknown. In particular, brain imaging has not been used to link neurosteroid effects to emotion regulation neurocircuitry.
To investigate the brain basis of allopregnanolone's impact on emotion regulation, participants were administered 400 mg of pregnenolone (n=16) or placebo (n=15) and underwent 3T functional magnetic resonance imaging while performing the shifted-attention emotion appraisal task, which probes emotional processing and regulation.
Compared with placebo, allopregnanolone was associated with reduced activity in the amygdala and insula across all conditions. During the appraisal condition, allopregnanolone increased activity in the dorsal medial prefrontal cortex and enhanced connectivity between the amygdala and dorsal medial prefrontal cortex, an effect that was associated with reduced self-reported anxiety.
These results demonstrate that in response to emotional stimuli, allopregnanolone reduces activity in regions associated with generation of negative emotion. Furthermore, allopregnanolone may enhance activity in regions linked to regulatory processes. Aberrant activity in these regions has been linked to anxiety psychopathology. These results thus provide initial neuroimaging evidence that allopregnanolone may be a target for pharmacologic intervention in the treatment of anxiety disorders and suggest potential future directions for research into neurosteroid effects on emotion regulation neurocircuitry.
Copyright © 2013 Society of Biological Psychiatry. All rights reserved.
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|Empirical Formula (Hill Notation)||C21H32O2|
|Application||5-PREGNEN-3β-OL-20-ONE (PregNENOlone) is a pheromone classified as a neurosteroid that is produced in both men and women. Closely associated with well-being and mood elevation it can be used as a stand-alone or paired with other pheromone molecules. Expect friendliness and happy feelings.|